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KMID : 0616120190500040260
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Korean Journal of Pharmacognosy
2019 Volume.50 No. 4 p.260 ~ p.271
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Thirteen Weeks Repeated Oral Dose Toxicity Study of Oplopanax elatus (Nakai) Nakai Hydrothermal Extract Powder in Sprague-Dawley Rats
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Yoo Nam-Ho
Kwon Yong-Soo
Chun Hyeon-Soo
Ahn Kyu-Sup
Kim Hye-Jin
Ryu Hyeon-Yeol
Lee So-Min
Song Kyung-Seuk
Park Byung-Jun
Kim Myong-Jo
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Abstract
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This study aimed to evaluate the safety of Oplopanax elatus (Nakai) Nakai hydrothermal extract powder. It was conducted using male and female Sprague-Dawley (SD) rats. The test group was established with dose of 500 (low-dosage group), 1,000 (medium- dosage group), and 2,000 (high- dosage group) mg/day. These are investigated that number of dead animals, general symptoms, weight changes, food consumption, ophthalmological examination, urinalysis, urine volume, hematological values, plasma coagulation time values, serum biochemical values, absolute organ weight, relative organ weight and histopathological finding during the experiment. As a result of the above, toxicological changes were not observed. Therefore, the non-toxic content of Oplopanax elatus (Nakai) Nakai hydrothermal extract powder is determined to be 2,000 mg/kg/day, and target organ was not observed.
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KEYWORD
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Dose, Oplopanax elatus (Nakai) Nakai, Oral, Rat, Toxicity
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